Proto-Oncogene Protein trk

《英文msh詞典》Proto-Oncogene Protein trk
[同義詞] Proto-Oncogene Protein trk
[主題詞] Receptor,trkA
[中文釋義] 原癌基因蛋白質trk
[英文釋義] A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4,neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with congenital insensitivity to pain with anhidrosis,while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.